Pubblicazioni

Herpes simplex virus type 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in Western countries. Some HSE children carry inborn errors of the Toll-like receptor 3 (TLR3)-dependent IFN-α/β– and -λ–inducing pathway. Induced pluripotent stem cell (iPSC)-derived cortical neurons with TLR3 pathway mutations are highly susceptible to HSV-1, due to impairment of cell-intrinsic […]

The Basel Committee on Banking Supervision has proposed a methodology to identify Systemically Important Financial Institutions based on a series of indicators that should account for the externalities that these institutions place into the system. In this article we argue that the methodology chosen by Basel III maintains the micro-prudential focus of Basel I and […]

Scientific production is steadily growing, exhibiting 4% annual growth in publications and 1.8% annual growth in the number of references per publication, together producing a 12-year doubling period in the total supply of references, i.e. links in the science citation network. This growth has far-reaching implications for how academic knowledge is connected, accessed and evaluated. […]

Subclonal architectures are prevalent across cancer types. However, the temporal evolutionary dynamics that produce tumor subclones remain unknown. Here we measure clone dynamics in human cancers by using computational modeling of subclonal selection and theoretical population genetics applied to high-throughput sequencing data. Our method determined the detectable subclonal architecture of tumor samples and simultaneously measured […]

The corticospinal tract is a critical white matter pathway as it connects the primary motor cortex to the spinal cord and handles voluntary motion. Atlases of major brain connections do exist, but, surprisingly, atlases that depict the actual localisation of a specific pathway are missing. In this work, we propose a comprehensive statistical methodology for […]