Human Technopole

The new call for Access to the National Facilities services is now open! The Human Technopole’s National Facilities continue to expand their support for cutting-edge research by launching the first Call for Access of 2025. Building on the success of the 24-PILOT call, to which over 120 projects have applied, this new opportunity allows researchers to benefit from state-of-the-art technologies and expertise.

Human Technopole is honoured to have participated in today’s meeting at the Quirinale, where President of the Republic Sergio Mattarella welcomed a delegation from MIND on the occasion of the tenth anniversary of the universal exposition Milano EXPO 2015.

By developing a sophisticated in vitro system coupled with advanced imaging techniques and CRISPR genome editing, an international team of researchers from Human Technopole (Italy) and the TUD Dresden University of Technology (Germany) shows that tubulin tyrosination/detyrosination regulates the bidirectional IFT train movement and avoids collision between trains moving in opposite directions along the cilium. The research was funded by the ERC and the DFG “Physics of Life” Excellence Cluster. The results are published in Nature Communications.

Meet Carlos Jimenez, Postdoc in the Bienko Group (Genomics), who has been awarded a prestigious Marie Skłodowska-Curie Actions Postdoctoral Fellowship from the European Union. The grant, totalling €172,750.08 and covering a two-year period, will support his groundbreaking project PRUNE – Uncovering the Proteomic Radial Organisation within the Eukaryotic Nucleus – to study how the spatial arrangement of nuclear proteins contributes to optimal cell functioning.

Oliver Harschnitz has been awarded a FIS Starting Grant for his proposal “Dissecting HSV-1 Latency and Reactivation using Trigeminal Organoids,” receiving funding of 1.3 million euros. The project, starting in March 2025, will run for three years.

Using advanced cryo-electron microscopy and cross-linking mass spectrometry, HT researchers provide unprecedented insight into how SNAPc works as a “dual recruiter” for RNA Polymerase II and III. The findings are published in Nature Communications.