Improving

human life

and technology

Welcome to Human Technopole

Highlights

  • A polarized cortical assembly showing a spatial gradient of expression along its longitudinal axis (from left to right, colors from blue to yellow-red). @Camilla Bosone (IMBA)

    A new model system for cortical development in vitro

    Researchers from Human Technopole, the Institute of Molecular Biotechnology and Bicocca University established a method for developing brain assembloids that allows reproducing salient aspects of the antero-posterior polarity of the human cerebral cortex in vitro and opens new possibilities for disease modelling. The study is published in Nature Methods.

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  • The National Facility for Genomics with Clelia Peano

    Meet Clelia Peano, Head of the National Facility for Genomics. The Facility offers cutting-edge services to develop robust experimental and analytical workflows to explore different genomic research areas, including DNA and RNA analysis, chromatin structure, and epigenetic mechanisms regulating transcription. The goal is to enhance genomic research in all its aspects, benefiting the entire Italian scientific community.

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  • SOLIST: Towards a Biopsy at the Nanoscale

    Human Technopole researchers have developed an improved cryo-lift out technique: Serialized On-grid Lift-in Sectioning for Tomography (SOLIST). SOLIST is a significant upgrade over previous approaches and allows imaging tissues to reveal their native organization at a molecular level with a throughput previously impossible. The results of the research are published in Nature Methods.

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  • The “tubulin code” in control of ciliary beating

    Using advanced cryo-electron microscopy techniques and mutational analysis, HT researchers show that protofilament-specific patterns of tubulin polyglutamylation and glycylation promote the direct binding of axonemal proteins to the ciliary axoneme, thus modulating ciliary beating. The findings are published in Current Biology.

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Research at HT

Improving human life and technology by investing in human health and prevention research is the ultimate goal of Human Technopole. We need to prevent and cure diseases to allow people of all ages to not only live longer, but also live better.

To accomplish its mission, HT’s research strives to unravel fundamental mechanisms relevant to human physiology and disease using a multi-scale systems biology approach, based on a combination of experimental research and theory, coupled with computational biology and Artificial Intelligence.

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Shared Research Infrastructure

To fulfil the needs of the Italian life science research community, HT infrastructure includes 5 National Facilities, serving as technological hubs and incubators for developing and disseminating new tools and methodologies and for carrying out top-level research.

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Courses and Conferences

The overarching and inspiring theme for HT’s external training activities is to create at HT a centre of excellence for training promising researchers in the biomedical sciences, while providing broad access to HT’s expertise, methods, and resources to the external community. Courses and conferences are supported by institutional and external funding, and sponsorships are welcome.
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Work with us

We offer the opportunity to be part of a new, dynamic research institute promoting a highly collaborative and international working environment.

We aim to attract the best resources in each field with a selection based on merit and transparency as we believe that highly diverse teams produce the best and most innovative results.

If you are a passionate person who likes to seize great challenges, consider applying for one of our scientific or administrative vacancies. 

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