28 July 2022

New tools for the analysis of CRISPR-Cas9 screens

Supervised classification methods can be used for the analysis of genetic screens obtained through the CRISPR-Cas9 genome editing technology. Nevertheless, these methods require large sets of reference genes to be included among those targeted with CRISPR. Alessandro Vinceti, of the Iorio Group, presents a novel computational method to identify reference gene sets of minimal size […]

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25 July 2022

A new approach to investigate the impact of retrotransposon recombination on human genome

Recombination of retrotransposons is known to affect genome stability and evolution, yet the significance of this process and its impact on the genome of human somatic cells are poorly understood. Giovanni Pascarella and Piero Carninci set up a new framework enabling comprehensive studies of retrotransposon recombination-driven genomic diversity in healthy and diseased tissues. The DNA […]

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20 July 2022

Francesca Ieva on Lombardy Region Taskforce

Our Associate Head of the Health Data Science Centre has been appointed to a new task force created by Lombardy Region which aims to reduce waiting lists and verify the proper management in the provision of health services to citizens. The task force includes members from Lombardy Region Welfare General Management, ATS, ASST, Lombardy Health […]

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18 July 2022

HT at the 23rd International Exhibition of Triennale Milano

The works on display at the 23rd International Exhibition, “Unknown Unknowns. An Introduction to Mysteries”, also include two microscopy images created by Human Technopole researchers. The unknown, the mysterious, what we “know we don’t know”. This is the theme at the heart of the exhibition, curated by Ersilia Vaudo, astrophysicist and Chief Diversity Officer of […]

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14 July 2022

Mapping spontaneous DNA double-strand breaks in neural cells

DNA double-strand breaks (DSBs) can cause mutations and genomic rearrangements resulting in genome instability thus contributing to the onset of genetic disorders and cancer. Magda Bienko and Nicola Crosetto provide tools and resources to investigate spontaneous DSBs that arise in an in vitro model of neurodevelopmental disorder pathogenesis. DNA damage can be either induced by […]

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