Human Technopole is now an Associate Partner of LifeTime, the pan-European research initiative that aims to revolutionise healthcare by tracking and understanding human diseases at single cell resolution to transform patients’ care and the sustainability of healthcare systems.
Joining the LifeTime community is an important opportunity for Human Technopole to build a strategic network of relevant European partners that share our ambition and goals.
Human Technopole’s mission is fully aligned with LifeTime’s overarching aim to tackle complex human diseases. Specifically, the three defining pillars of LifeTime (single-cell multiomics, organoids and machine learning-based deconvolution) are represented in HT by the close integration of Centres and Core Facilities featuring leading expertise in these fields.
Together with the University of Milan, the European Institute of Oncology (IEO) and the Sacco Hospital, Human Technopole is already part of the Italian branch of the initiative Lifetime for COVID19, which for the upcoming two years will be led by the Head of our Research Centre for Neurogenomics, Prof. Giuseppe Testa.
The LifeTime consortium gathers over 120 leading scientists from over 90 European research institutes. The University of Milan is the Italian partner of the consortium and other Italian associate partners include the European Institute of Oncology, Fondazione Istituto FIRC di Oncologia Molecolare, the Institute for Biomedical Technologies and the Institute of Photonics and Nanotechnologies of the Italian National Research Council as well as many prominent Italian universities.
The Glastonbury Group is among the recipients of the Data Insights Cycle 3 awards. The aim of the grant is to develop a machine learning model that identifies disease-relevant cell subpopulations whilst predicting a phenotype/disease of interest from large-scale single-cell RNA-seq data.
In collaboration with an international team of scientists, HT researchers identified a missense mutation in a gene involved in brain-intrinsic immunity as the genetic cause of SARS-CoV-2 brainstem encephalitis.
A study by Human Technopole, the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust in London has shown that in prostate cancer the presence in the same tumour of cells with large differences in shape and genetic composition indicates an increased risk of relapse, including after a decade. The study may help doctors better tailor treatment for this disease, adopting more aggressive therapies in cases where these parameters indicate a higher risk of disease recurrence.
Human Technopole is opening its National Facilities, providing advanced equipment and technologies accessible through calls for proposals open to the Italian scientific community. Projects will be selected by a commission of international experts. Scientists will have access to five new dedicated facilities, which act as catalysts for open innovation in the life sciences sector, crucial for research and the health of Italians.
An international team of scientists led by HT researchers Magda Bienko and Nicola Crosetto developed an open-source software for deconvolution of widefield fluorescence microscopy image stacks and large tissue scans. This new tool increases the information obtained with fluorescence microscopy-based spatial omic methods.
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