Gaia Pigino

Gaia Pigino

Gaia Pigino is a biologist, currently Associate Head of the Structural Biology Center at Human Technopole, after 9 years as Research Group Leader at the Max Planck Institute CBG in Dresden. She collaborate with Alessandro Vannini to develop the Centre for Structural Biology. Gaia’s laboratory studies molecular mechanisms and principles of self-organisation in cilia and other subcellular structures that are of fundamental importance for human health and disease.

CURRENT POSITION

Since 2021 Associate Head of the Structural Biology Center at Human Technopole, Milan, Italy
Since 2012 Research Group Leader at MPI-CBG, the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

POSTDOCTORAL RESEARCH

2010-2012 Postdoctoral EMBO Long Term fellow Laboratory of Biomolecular Research (BMR), Department of Biology and Chemistry, Paul Scherer Institute (PSI) Switzerland. Supervisor: Prof. T. Ishikawa.
2009-2011 Postdoctoral researcher Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland. Supervisor: Prof. T. Ishikawa.
2007-2009 Postdoctoral MIUR research fellow Fellowship of the “Ministero Italiano dell’Istruzione, dell’Università e della Ricerca”. Laboratory of Cryotechniques for Electron Microscopy, Department of Evolutionary Biology, University of Siena. Supervisor: Prof. P. Lupetti.
2009 Participant at the Physiology Course at MBL in Woods Hole Marine Biological Laboratory, Woods Hole. Directors: Dyche Mullins and Claire Waterman.

EDUCATION

2003-2007 Ph.D. Student (Ph.D. Fellowship by the Italian government “Ministero Italiano dell’Istruzione, dell’Università e della Ricerca”). Department of Evolutionary Biology, University of Siena. Supervisor: Prof. F. Bernini and Prof. C. Leonzio.
2002 Diploma in Natural Science (Summa cum laude). University of Siena, Italy. Thesis supervisors: Prof. C. Leonzio and Prof. F. Bernini.

OTHER POSITIONS

2003 Research Associate. Department of Environmental Sciences G. Sarfatti, University of Siena. Advisor: Prof. C. Leonzio

AWARDS and FUNDING

2022 EMBO Member
2019 DFG Grant – GAČR-DFG Cooperation
2018 PoL starting fellowship (from the Dresden Excellence Cluster ‘Physics of Life’)
2018 Keith R. Porter Fellow Award for Cell Biology
2018 ERC Consolidator Grant (ERC-2018-COG N#819826 CiliaTubulinCode)
2018 Excellence Cluster ‘Physics of Life’, as a core Principal Investigator
2010 EMBO Long Term fellowship
2009 Scholarship from the Marine Biological Laboratory (Woods Hole, Massachusetts) MBL Physiology Course.
2007 Post-Doctoral Research fellowship from MIUR.
2003 Ph.D. Fellowship from MIUR.

Fellowship to students and postdocs

2022 EMBO Long Term Fellowship to Helen Foster
2021 EMBO Postdoc Fellowship to Nikolai Klena
2019 HFSP Postdoc Fellowship to Adrian Nievergelt
2018 EMBO Long Term Fellowship to Adrian Nievergelt
2017 Marie Curie Fellowship to Adam Schröfel (H2020-MSCA-IF-2016)
2015 DIGS-BB Fellowship to Guendalina Marini
2012 DIGS-BB Fellowship to Ludek Stepanek

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Publications

  • 10/2017 - Molecular Biology of the Cell

    Microtubule dynamics: 50 years after the discovery of tubulin and still going strong

    The Minisymposium “Microtubule Dynamics” featured speakers ranging from a founding member of the microtubule field to graduate students embarking on their scientific journeys. The session spanned a broad range of topics, from fundamental questions about the structure and dynamics of microtubules, to the behavior of molecular motors in reconstituted systems, to the therapeutic potential of […]

  • 07/2017 - Nature Structural & Molecular Biology

    Switching dynein motors on and off

    Cytoplasmic dyneins transport cellular components from the periphery toward the center of the cell. By moving cargoes along microtubules, dyneins ensure proper cell division, regulate exchange of materials between organelles, and contribute to the internal organization of eukaryotic cells. Two recent studies show that, upon dimerization, cytoplasmic dyneins intrinsically adopt an autoinhibited configuration that can […]

  • 04/2017 - Methods in Cell Biology

    Millisecond time resolution correlative light and electron microscopy for dynamic cellular processes

    Molecular motors propel cellular components at velocities up to microns per second with nanometer precision. Imaging techniques combining high temporal and spatial resolution are therefore indispensable to understand the cellular mechanics at the molecular level. For example, intraflagellar transport (IFT) trains constantly shuttle ciliary components between the base and tip of the eukaryotic cilium. 3-D […]

  • 05/2016 - Science

    Microtubule doublets are double-track railways for intraflagellar transport trains

    The cilium is a large macromolecular machine that is vital for motility, signaling, and sensing in most eukaryotic cells. Its conserved core structure, the axoneme, contains nine microtubule doublets, each comprising a full A-microtubule and an incomplete B-microtubule. However, thus far, the function of this doublet geometry has not been understood. We developed a time-resolved […]

  • 10/2015 - American Journal of Respiratory Cell and Molecular Biology

    DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes

    Primary ciliary dyskinesia (PCD) is a recessively inherited disease that leads to chronic respiratory disorders owing to impaired mucociliary clearance. Conventional transmission electron microscopy (TEM) is a diagnostic standard to identify ultrastructural defects in respiratory cilia but is not useful in approximately 30% of PCD cases, which have normal ciliary ultrastructure. DNAH11 mutations are a common cause […]