Gaia Pigino

Gaia Pigino

Gaia Pigino is a biologist, currently Associate Head of the Structural Biology Center at Human Technopole, after 9 years as Research Group Leader at the Max Planck Institute CBG in Dresden. She collaborate with Alessandro Vannini to develop the Centre for Structural Biology. Gaia’s laboratory studies molecular mechanisms and principles of self-organisation in cilia and other subcellular structures that are of fundamental importance for human health and disease.

CURRENT POSITION

Since 2021 Associate Head of the Structural Biology Center at Human Technopole, Milan, Italy
Since 2012 Research Group Leader at MPI-CBG, the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

POSTDOCTORAL RESEARCH

2010-2012 Postdoctoral EMBO Long Term fellow Laboratory of Biomolecular Research (BMR), Department of Biology and Chemistry, Paul Scherer Institute (PSI) Switzerland. Supervisor: Prof. T. Ishikawa.
2009-2011 Postdoctoral researcher Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland. Supervisor: Prof. T. Ishikawa.
2007-2009 Postdoctoral MIUR research fellow Fellowship of the “Ministero Italiano dell’Istruzione, dell’Università e della Ricerca”. Laboratory of Cryotechniques for Electron Microscopy, Department of Evolutionary Biology, University of Siena. Supervisor: Prof. P. Lupetti.
2009 Participant at the Physiology Course at MBL in Woods Hole Marine Biological Laboratory, Woods Hole. Directors: Dyche Mullins and Claire Waterman.

EDUCATION

2003-2007 Ph.D. Student (Ph.D. Fellowship by the Italian government “Ministero Italiano dell’Istruzione, dell’Università e della Ricerca”). Department of Evolutionary Biology, University of Siena. Supervisor: Prof. F. Bernini and Prof. C. Leonzio.
2002 Diploma in Natural Science (Summa cum laude). University of Siena, Italy. Thesis supervisors: Prof. C. Leonzio and Prof. F. Bernini.

OTHER POSITIONS

2003 Research Associate. Department of Environmental Sciences G. Sarfatti, University of Siena. Advisor: Prof. C. Leonzio

AWARDS and FUNDING

2022 EMBO Member
2019 DFG Grant – GAČR-DFG Cooperation
2018 PoL starting fellowship (from the Dresden Excellence Cluster ‘Physics of Life’)
2018 Keith R. Porter Fellow Award for Cell Biology
2018 ERC Consolidator Grant (ERC-2018-COG N#819826 CiliaTubulinCode)
2018 Excellence Cluster ‘Physics of Life’, as a core Principal Investigator
2010 EMBO Long Term fellowship
2009 Scholarship from the Marine Biological Laboratory (Woods Hole, Massachusetts) MBL Physiology Course.
2007 Post-Doctoral Research fellowship from MIUR.
2003 Ph.D. Fellowship from MIUR.

Fellowship to students and postdocs

2022 EMBO Long Term Fellowship to Helen Foster
2021 EMBO Postdoc Fellowship to Nikolai Klena
2019 HFSP Postdoc Fellowship to Adrian Nievergelt
2018 EMBO Long Term Fellowship to Adrian Nievergelt
2017 Marie Curie Fellowship to Adam Schröfel (H2020-MSCA-IF-2016)
2015 DIGS-BB Fellowship to Guendalina Marini
2012 DIGS-BB Fellowship to Ludek Stepanek

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Publications

  • 10/2015 - Journal of Structural Biology

    Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography

    We demonstrate absolute quantitative mass density mapping in three dimensions of frozen-hydrated biological matter with an isotropic resolution of 180 nm. As model for a biological system we use Chlamydomonas cells in buffer solution confined in a microcapillary. We use ptychographic X-ray computed tomography to image the entire specimen, including the 18 μm-diameter capillary, thereby […]

  • 05/2015 - Optics Express

    Artifact characterization and reduction in scanning X-ray Zernike phase contrast microscopy

    Zernike phase contrast microscopy is a well-established method for imaging specimens with low absorption contrast. It has been successfully implemented in full-field microscopy using visible light and X-rays. In microscopy Cowley’s reciprocity principle connects scanning and full-field imaging. Even though the reciprocity in Zernike phase contrast has been discussed by several authors over the past […]

  • 03/2013 - Methods in Enzymology

    Electron tomography of IFT particles

    Cilia and flagella play very important roles in eukaryotic cells, ranging from cell motility to chemo- and mechanosensation with active involvement in embryonic development and control of cell division. Cilia and flagella are highly dynamic organelles undergoing constant turnover at their tip, where multiprotein precursors synthesized in the cell cytoplasm are assembled, turnover products are […]

  • 05/2012 - Journal of Structural Biology

    Comparative structural analysis of eukaryotic flagella and cilia from Chlamydomonas, Tetrahymena, and sea urchins

    Although eukaryotic flagella and cilia all share the basic 9 + 2 microtubule-organization of their internal axonemes, and are capable of generating bending-motion, the waveforms, amplitudes, and velocities of the bending-motions are quite diverse. To explore the structural basis of this functional diversity of flagella and cilia, we here compare the axonemal structure of three different organisms with […]

  • 03/2012 - BioArchitecture

    Axonemal radial spokes: 3D structure, function and assembly

    The radial spoke (RS) is a complex of at least 23 proteins that works as a mechanochemical transducer between the central‐pair apparatus and the peripheral microtubule doublets in eukaryotic flagella and motile cilia. The RS contributes to the regulation of the activity of dynein motors, and thus to flagellar motility. Despite numerous biochemical, physiological and […]