Gaia Pigino
- Associate Head of Structural Biology Research Centre, Structural biology
- Research Group Leader, Pigino Group
Gaia Pigino is a biologist, currently Associate Head of the Structural Biology Center at Human Technopole, after 9 years as Research Group Leader at the Max Planck Institute CBG in Dresden. She collaborate with Alessandro Vannini to develop the Centre for Structural Biology. Gaia’s laboratory studies molecular mechanisms and principles of self-organisation in cilia and other subcellular structures that are of fundamental importance for human health and disease.
CURRENT POSITION
| Since 2021 | Associate Head of the Structural Biology Center at Human Technopole, Milan, Italy |
| Since 2012 | Research Group Leader at MPI-CBG, the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany |
POSTDOCTORAL RESEARCH
| 2010-2012 | Postdoctoral EMBO Long Term fellow Laboratory of Biomolecular Research (BMR), Department of Biology and Chemistry, Paul Scherer Institute (PSI) Switzerland. Supervisor: Prof. T. Ishikawa. |
| 2009-2011 | Postdoctoral researcher Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland. Supervisor: Prof. T. Ishikawa. |
| 2007-2009 | Postdoctoral MIUR research fellow Fellowship of the “Ministero Italiano dell’Istruzione, dell’Università e della Ricerca”. Laboratory of Cryotechniques for Electron Microscopy, Department of Evolutionary Biology, University of Siena. Supervisor: Prof. P. Lupetti. |
| 2009 | Participant at the Physiology Course at MBL in Woods Hole Marine Biological Laboratory, Woods Hole. Directors: Dyche Mullins and Claire Waterman. |
EDUCATION
| 2003-2007 | Ph.D. Student (Ph.D. Fellowship by the Italian government “Ministero Italiano dell’Istruzione, dell’Università e della Ricerca”). Department of Evolutionary Biology, University of Siena. Supervisor: Prof. F. Bernini and Prof. C. Leonzio. |
| 2002 | Diploma in Natural Science (Summa cum laude). University of Siena, Italy. Thesis supervisors: Prof. C. Leonzio and Prof. F. Bernini. |
OTHER POSITIONS
| 2003 | Research Associate. Department of Environmental Sciences G. Sarfatti, University of Siena. Advisor: Prof. C. Leonzio |
AWARDS and FUNDING
| 2022 | EMBO Member |
| 2019 | DFG Grant – GAČR-DFG Cooperation |
| 2018 | PoL starting fellowship (from the Dresden Excellence Cluster ‘Physics of Life’) |
| 2018 | Keith R. Porter Fellow Award for Cell Biology |
| 2018 | ERC Consolidator Grant (ERC-2018-COG N#819826 CiliaTubulinCode) |
| 2018 | Excellence Cluster ‘Physics of Life’, as a core Principal Investigator |
| 2010 | EMBO Long Term fellowship |
| 2009 | Scholarship from the Marine Biological Laboratory (Woods Hole, Massachusetts) MBL Physiology Course. |
| 2007 | Post-Doctoral Research fellowship from MIUR. |
| 2003 | Ph.D. Fellowship from MIUR. |
Fellowship to students and postdocs
| 2022 | EMBO Long Term Fellowship to Helen Foster |
| 2021 | EMBO Postdoc Fellowship to Nikolai Klena |
| 2019 | HFSP Postdoc Fellowship to Adrian Nievergelt |
| 2018 | EMBO Long Term Fellowship to Adrian Nievergelt |
| 2017 | Marie Curie Fellowship to Adam Schröfel (H2020-MSCA-IF-2016) |
| 2015 | DIGS-BB Fellowship to Guendalina Marini |
| 2012 | DIGS-BB Fellowship to Ludek Stepanek |
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Publications
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10/2015 - Journal of Structural Biology
Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography
We demonstrate absolute quantitative mass density mapping in three dimensions of frozen-hydrated biological matter with an isotropic resolution of 180 nm. As model for a biological system we use Chlamydomonas cells in buffer solution confined in a microcapillary. We use ptychographic X-ray computed tomography to image the entire specimen, including the 18 μm-diameter capillary, thereby […]
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05/2015 - Optics Express
Artifact characterization and reduction in scanning X-ray Zernike phase contrast microscopy
Zernike phase contrast microscopy is a well-established method for imaging specimens with low absorption contrast. It has been successfully implemented in full-field microscopy using visible light and X-rays. In microscopy Cowley’s reciprocity principle connects scanning and full-field imaging. Even though the reciprocity in Zernike phase contrast has been discussed by several authors over the past […]
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03/2013 - Methods in Enzymology
Electron tomography of IFT particles
Cilia and flagella play very important roles in eukaryotic cells, ranging from cell motility to chemo- and mechanosensation with active involvement in embryonic development and control of cell division. Cilia and flagella are highly dynamic organelles undergoing constant turnover at their tip, where multiprotein precursors synthesized in the cell cytoplasm are assembled, turnover products are […]
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05/2012 - Journal of Structural Biology
Comparative structural analysis of eukaryotic flagella and cilia from Chlamydomonas, Tetrahymena, and sea urchins
Although eukaryotic flagella and cilia all share the basic 9 + 2 microtubule-organization of their internal axonemes, and are capable of generating bending-motion, the waveforms, amplitudes, and velocities of the bending-motions are quite diverse. To explore the structural basis of this functional diversity of flagella and cilia, we here compare the axonemal structure of three different organisms with […]
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03/2012 - BioArchitecture
Axonemal radial spokes: 3D structure, function and assembly
The radial spoke (RS) is a complex of at least 23 proteins that works as a mechanochemical transducer between the central‐pair apparatus and the peripheral microtubule doublets in eukaryotic flagella and motile cilia. The RS contributes to the regulation of the activity of dynein motors, and thus to flagellar motility. Despite numerous biochemical, physiological and […]
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