06/2020 - Modeling the Effect of Recurrent Events on Time-to-event Processes by Means of Functional Data
In this paper we propose a methodological framework for modeling information carried out by a longitudinal process by means of functional data, within a survival framework targeting the time-to-event process of interest. In particular, the longitudinal process is represented by the compensator of a marked point process the recurrent events are supposed to derive from. […]
06/2020 - Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection
RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because viral polymerases cleave 5′-m7G-capped host transcripts to prime viral mRNA synthesis (“cap-snatching”). We hypothesized that start codons within cap-snatched host transcripts could generate chimeric human-viral […]
06/2020 - Economic and social consequences of human mobility restrictions under COVID-19
In response to the coronavirus disease 2019 (COVID-19) pandemic, several national governments have applied lockdown restrictions to reduce the infection rate. Here we perform a massive analysis on near–real-time Italian mobility data provided by Facebook to investigate how lockdown strategies affect economic conditions of individuals and local governments. We model the change in mobility as […]
06/2020 - The sociability spectrum: evidence from reciprocal genetic copy number variations
Sociability entails some of the most complex behaviors processed by the central nervous system. It includes the detection, integration, and interpretation of social cues and elaboration of context-specific responses that are quintessentially species-specific. There is an ever-growing accumulation of molecular associations to autism spectrum disorders (ASD), from causative genes to endophenotypes across multiple functional layers; […]
06/2020 - KMT2B and Neuronal Transdifferentiation: Bridging Basic Chromatin Mechanisms to Disease Actionability
The role of bona fide epigenetic regulators in the process of neuronal transdifferentiation was until recently largely uncharacterized, despite their key role in the physiological processes of neural fate acquisition and maintenance. In this commentary, we describe the main findings of our recent paper “KMT2B is selectively required for neuronal transdifferentiation, and its loss exposes dystonia candidate […]
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