11/2019 - TFIIIC Binding to Alu Elements Controls Gene Expression via Chromatin Looping and Histone Acetylation
How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu elements (AEs) and RNA polymerase III transcription factor C (TFIIIC) in structurally and functionally modulating the genome via chromatin looping and histone acetylation. Upon serum deprivation, a subset […]
11/2019 - O2S2: A new venue for computational geostatistics
Applied sciences have witnessed an explosion of georeferenced data. Object oriented spatial statistics (O2S2) is a recent system of ideas that provides a solid framework where the new challenges posed by the GeoData revolution can be faced, by grounding the analysis on a powerful geometrical and topological approach. We shall present a perspective on O2S2, […]
10/2019 - Spatial heterogeneity in non-parametric efficiency: An application to Italian hospitals
This paper introduces a new empirical procedure for the estimation of hospitals’ technical efficiency in presence of spatial heterogeneity. We propose a methodology that allows treating spatial heterogeneity independently of a predetermined reference to administrative borders. We define geographical spatial regimes, characterised by spatial proximity and homogeneity of relevant demand characteristics, within which to assess […]
09/2019 - Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
Immune-disease-associated variants are enriched in active chromatin regions of T cells and macrophages. However, whether these variants function in specific cell states is unknown. Here we stimulated T cells and macrophages in the presence of 13 cytokines and profiled active and open chromatin regions. T cell activation induced major chromatin remodeling, while the presence of […]