05/2019 - Turning big data into smart data: two examples based on the analysis of the Mappa dei Rischi dei Comuni Italiani
The recently presented Mappa dei Rischi dei Comuni Italiani is a freely accessible web portal, implemented by ISTAT, which provides integrated data on different natural risks in Italian municipalities together with socio-economic and demographic data We here illustrate two paradigmatic examples where the big data of the Mappa are transformed into smart data using advanced […]
05/2019 - Long-term correlations in short, non-stationary time series: An application to international R&D collaborations
Within the perimeter of patent collaboration networks, the average distance of collaborations and the number of countries involved per each collaboration have been shown to have increased steadily in time. Less attention, though, has been devoted to assessing whether this growth of cross-country collaborations is stable in time. To address this scientific question we focus […]
12/2018 - Nonparametric frailty Cox models for hierarchical time-to-event data
We propose a novel model for hierarchical time-to-event data, for example, healthcare data in which patients are grouped by their healthcare provider. The most common model for this kind of data is the Cox proportional hazard model, with frailties that are common to patients in the same group and given a parametric distribution. We relax […]
12/2018 - A personalized mathematical tool for neuro-oncology: A clinical case study
This work evaluates the predictive ability of a novel personalized computational tool for simulating the growth of brain tumours using the neuroimaging data collected during one clinical case study. The mathematical model consists of an evolutionary fourth-order partial differential equation with degenerate motility, in which the spreading dynamics of the multiphase tumour is coupled with […]
11/2018 - The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia
Movement of cargos along microtubules plays key roles in diverse cellular processes, from signalling to mitosis. In cilia, rapid movement of ciliary components along the microtubules to and from the assembly site is essential for the assembly and disassembly of the structure itself1. This bidirectional transport, known as intraflagellar transport (IFT)2, is driven by the […]