19 December 2022

OPEN HT: a dialogue with the scientific community

Today Monday 19 December from 10.00 a.m. in the Human Technopole Auditorium at MIND Milano Innovation District OPEN HT took place. The event represented an opportunity for dialogue between the life sciences Institute and the national scientific community. The initiative was also the occasion to share the developments of Human Technopole as detailed in the […]

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25 November 2022

Introducing Ivano Legnini

Ivano Legnini is an Italian molecular and systems biologist interested in gene regulation. He currently lives in Berlin, working at the Max Delbrück Center – Berlin Institute for Medical Systems Biology, in the lab of Nikolaus Rajewsky. Ivano did his PhD in the lab of Irene Bozzoni at Sapienza University of Rome, where he also […]

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16 November 2022

How APOE4 affects human brain in Alzheimer’s disease

Apolipoprotein E (APOE) is a small protein encoded by the APOE gene regulating lipid homeostasis in mammals.  The e4 variant of the APOE gene (APOE4) is associated with an increased risk of developing Alzheimer’s disease (AD) in mammals. A Nature study co-authored by Jose Davila-Velderrain reveals cell-type specific effects of APOE4 on cholesterol metabolism and […]

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07 November 2022

Measuring chromatin compaction with FRET-FISH

DNA intercalating dyes and massively sequencing techniques are traditionally used to study nuclear chromatin compaction. These tools, however, do not allow for direct measurement of chromatin compaction of individual loci. Nicola Crosetto and Magda Bienko combine fluorescence resonance energy transfer (FRET) with DNA fluorescence in situ hybridization (FISH) to assess the level of chromatin compaction […]

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26 October 2022

Exploring The ‘Dark Matter’ Of Colorectal Cancer

An international study co-ordinated by Andrea Sottoriva, Head of Human Technopole’s Computational Biology Research Centre, together with researchers from the Institute for Cancer Research (ICR) in London, reveals that key changes that explain mechanistic aspects of the onset and development of intestinal tumours come not only from genetic mutations, but also from so-called ‘epigenetics’ and […]

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