Project Score database: a resource that will help designing the next generation of anti-cancer drugs
A new paper published by Nuclear Acids Research and co-authored by Francesco Iorio, Group Leader at the Centre for Computational Biology, describes the creation of Project Score: a web portal enabling users to estimate the potential of each gene as a therapeutic target of future anti-cancer drugs.
Project Score, created and maintained by the group of Mathew Garnett at the Wellcome Sanger Institute, allows to browse data, download free datasets, and investigate specific biological hypotheses. For example, by specifying the name of any gene, the system will offer additional information on the gene’s target-priority score, potential biomarkers and tractability, including whether there are already drugs available to inhibit the corresponding coded protein.
The data underlying this resource has been made available thanks to CRISPR Cas9 whole-genome drop out screens which allow to better understand gene function and identify dependencies in cancer cells. The system is based on a computational pipeline developed by Francesco Iorio, Fiona Behan and Mathew Garnett and data described in a paper published last year in Nature, as part of the Cancer Dependency Map initiative.
Share:
You could also like:
-
Human Technopole Towards More Sustainable and Open Research
The HT Auditorium at the heart of the MIND district, hosted the presentation of the fifth edition of its Integrated Report, illustrating the first year of implementation of the 2024–2028 Strategic Plan. The document highlights the Institute’s scientific impact and its growing integration within Italy’s life sciences ecosystem, showcasing Human Technopole’s ongoing sustainable transformation throughout 2024.
-
Together for World Food Day at Human Technopole
Today is World Food Day, and we at Human Technopole are proud to share how we have recently joined the Colletta MIND food drive, organised in collaboration with other organisations at MIND – Milano Innovation District and with Banco Alimentare. For over 35 years, Banco Alimentare has been a key player in the fight against food waste and food insecurity, helping families and individuals in need across Italy.
-
Human Technopole’s National Facilities: New Call Opens with +36% in Proposals so far
Human Technopole’s National Facilities have launched their third round of access, starting 1 October 2025, inviting researchers to submit proposals for access to cutting-edge technologies in genomics, genome engineering, structural biology, light imaging, and data analysis. The opening comes in a context of strong momentum: since mid-2024, the National Facilities have received 293 proposals in total, with a 36% rise between the pilot and the first call, granting access to 184 projects with a success rate above 60%.
-
3 Fully-Funded PhD Positions in Data Analytics and Decision Sciences at HT
Are you passionate about AI, mathematical modelling, or genomics, and eager to work on high-impact research in biomedical science? Human Technopole is excited to offer three fully-funded PhD positions as part of the prestigious PhD Programme in Data Analytics and Decision Sciences!
-
FRRB funds the Glastonbury Group to study the immune landscape of pancreatic cancer
The Glastonbury Group at Human Technopole has been awarded a competitive grant as part of the “From Bed To Bench: the way to innovation” funding programme promoted by the Fondazione Regionale per la Ricerca Biomedica (FRRB). The study, funded with 2.000.000 euros, 600.000 of which will go to the Glastonbury group directly, will begin in late 2025 and run for 3 years.