Project Score database: a resource that will help designing the next generation of anti-cancer drugs
A new paper published by Nuclear Acids Research and co-authored by Francesco Iorio, Group Leader at the Centre for Computational Biology, describes the creation of Project Score: a web portal enabling users to estimate the potential of each gene as a therapeutic target of future anti-cancer drugs.
Project Score, created and maintained by the group of Mathew Garnett at the Wellcome Sanger Institute, allows to browse data, download free datasets, and investigate specific biological hypotheses. For example, by specifying the name of any gene, the system will offer additional information on the gene’s target-priority score, potential biomarkers and tractability, including whether there are already drugs available to inhibit the corresponding coded protein.
The data underlying this resource has been made available thanks to CRISPR Cas9 whole-genome drop out screens which allow to better understand gene function and identify dependencies in cancer cells. The system is based on a computational pipeline developed by Francesco Iorio, Fiona Behan and Mathew Garnett and data described in a paper published last year in Nature, as part of the Cancer Dependency Map initiative.
Share:
You could also like:
-
First Marie Curie Fellowships for Human Technopole
Two Human Technopole researchers have been awarded the Marie Curie postdoctoral fellowship, one of the most prestigious fellowships for early career researchers: Dr. Carlos Jiménez and Dr. Albert Navarro Gallinad. Dr. Navarro Gallinad’s research project, presented today on National Women’s Health Day, will investigate the environmental risks faced by pregnant women by analysing almost 1,000,000 births in Lombardy over the last twelve years. Dr. Jiménez will study how the spatial arrangement of nuclear proteins contributes to optimal cell functioning.
-
Human Technopole Celebrates its First PhDs
Three young scientists from Human Technopole have, for the first time since its foundation, obtained a doctoral degree while pursuing their research within the institute: Alessandro Vinceti, Davide Castaldi, and Marco Tullio Rigoli, all enrolled in the systems medicine programme of the European School of Molecular Medicine (SEMM).
-
Research and Design Converge in Milan
Milan also means research, and this year Human Technopole is taking part in the city’s promotional campaign for the Milan Design Week, which will take place from 15 to 21 April 2024.
-
HT Director’s Lectio Magistralis
Human Technopole’s Director Marino Zerial was invited last week to give the Lectio Magistralis during the inauguration ceremony of University of Genoa’s academic year 2023-2024.
-
Profiling extrachromosomal circular DNAs
A new sequencing method sheds light on the diversity and complexity of extrachromosomal circular DNAs (eccDNAs) in single cells.