Project Score database: a resource that will help designing the next generation of anti-cancer drugs
26 October 2020
Project Score database: a resource that will help designing the next generation of anti-cancer drugs
A new paper published by Nuclear Acids Research and co-authored by Francesco Iorio, Group Leader at the Centre for Computational Biology, describes the creation of Project Score: a web portal enabling users to estimate the potential of each gene as a therapeutic target of future anti-cancer drugs.
Project Score, created and maintained by the group of Mathew Garnett at the Wellcome Sanger Institute, allows to browse data, download free datasets, and investigate specific biological hypotheses. For example, by specifying the name of any gene, the system will offer additional information on the gene’s target-priority score, potential biomarkers and tractability, including whether there are already drugs available to inhibit the corresponding coded protein.
The data underlying this resource has been made available thanks to CRISPR Cas9 whole-genome drop out screens which allow to better understand gene function and identify dependencies in cancer cells. The system is based on a computational pipeline developed by Francesco Iorio, Fiona Behan and Mathew Garnett and data described in a paper published last year in Nature, as part of the Cancer Dependency Map initiative.
Which brain connections coordinate the sense of sight with movement, for example maintaining stable vision while walking or moving our eyes? How is cholesterol formed and what functions does it have in its intermediate steps? These are the topics of the research projects awarded the Early Career Fellowship Programme, a call for proposals launched by […]
The first symposium on “Gender Equality and Diversity at HT” took place today at the Human Technopole Auditorium. The aim of the event was to discuss why there are differences in the career outcomes of men and women and how we can act to promote equality and inclusion at HT. During the event we heard from Gerlind […]
The Supervisory Board of the Human Technopole Foundation has appointed Marino Zerial as the institute’s new Director. Currently Director of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, a research institution he helped found over 25 years ago, Marino Zerial is also an honorary professor at the Faculty of Medicine […]
Magda Bienko, Group Leader at the Functional Genomics Centre at Human Technopole has been awarded an ERC Consolidator Grant for her research project “Radialis”. The project, which has earned a funding of 2 million euros, aims to understand the design principles shaping genome architecture. Within our cells, DNA is folded in a three-dimensional structure. The […]
A web-based application developed by the Iorio Group and the IT & digitalisation team at Human Technopole helps non-computational scientists process and analyse CRISPR-Cas9 screens by reducing false-positive hits. CRISPR/Cas9 technology has become the gold standard for genome and epigenome editing, for studying the regulation of gene expression, and for high-throughput screenings aiming at identifying […]
Manage Cookie Consent
This website uses cookies. Technical cookies are required to allow proper functioning of the website. Third party cookies for statistics and profiling purposes are used only with prior consent. By selecting ACCEPT ALL you consent to all such cookies. You can find the full policy at the following link.
Technical cookies (required)
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.