Giuseppe Testa
- Head of Neurogenomics
- Research Group Leader, Testa Group
Giuseppe Testa è un medico, professore ordinario di Biologia Molecolare presso l’Università Statale di Milano e Direttore del High Definition Disease Modelling Lab: Stem Cell and Organoid Epigenetics dell’Istituto Europeo di Oncologia. A Human Technopole il prof. Testa guida il centro di Neurogenomica del programma di ricerca in convenzione con l’Università Statale di Milano. Il programma si occupa, fra l’altro, dei meccanismi molecolari alla base delle disabilità intellettive e dell’autismo.
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Pubblicazioni
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05/2022 - Frontiers in Neuroscience
EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation
The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and neurodevelopmental disorders, particularly with respect to the malfunction of sits catalytic subunit EZH2. Here, we investigated the role of the EZH2-mediated H3K27me3 apposition in […]
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04/2022 - BioRxiv
Benchmarking brain organoid recapitulation of fetal corticogenesis
Brain organoids are becoming increasingly relevant to dissect the molecular mechanisms underlying psychiatric and neurological conditions. The in vitro recapitulation of key features of human brain development affords the unique opportunity of investigating the developmental antecedents of neuropsychiatric conditions in the context of the actual patients’ genetic backgrounds. Specifically, multiple strategies of brain organoid (BO) differentiation have […]
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04/2022 - Cell Reports
CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories
Mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are a frequent cause of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses macrocephaly, implicating cortical abnormalities, how CHD8 haploinsufficiency affects neurodevelopmental is unclear. Here, employing human cerebral organoids, we find that CHD8 haploinsufficiency disrupted neurodevelopmental trajectories with an accelerated and delayed generation of, respectively, inhibitory and excitatory neurons that yields, at days 60 […]
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03/2022 - International Journal of Molecular Sciences
The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill […]
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