Giuseppe Testa
- Head of Neurogenomics
- Research Group Leader, Testa Group
Giuseppe Testa è un medico, professore ordinario di Biologia Molecolare presso l’Università Statale di Milano e Direttore del High Definition Disease Modelling Lab: Stem Cell and Organoid Epigenetics dell’Istituto Europeo di Oncologia. A Human Technopole il prof. Testa guida il centro di Neurogenomica del programma di ricerca in convenzione con l’Università Statale di Milano. Il programma si occupa, fra l’altro, dei meccanismi molecolari alla base delle disabilità intellettive e dell’autismo.
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Pubblicazioni
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10/2020 - Nature Communications
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency
The interplay between the Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) and transcriptional/epigenetic co-regulators in somatic cell reprogramming is incompletely understood. Here, we demonstrate that the histone H3 lysine 27 trimethylation (H3K27me3) demethylase JMJD3 plays conflicting roles in mouse reprogramming. On one side, JMJD3 induces the pro-senescence factor Ink4a and degrades the pluripotency regulator PHF20 in a […]
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09/2020 - Molecular Autism
Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology
The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds of genes, converging at the functional level on selective biological domains such as epigenetic regulation and synaptic function, have been identified to be either causative or risk factors of autism. On the other hand, exposure to […]
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09/2020 - Nature
LifeTime and improving European healthcare through cell-based interceptive medicine
LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of […]
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06/2020 - Molecular Autism
The sociability spectrum: evidence from reciprocal genetic copy number variations
Sociability entails some of the most complex behaviors processed by the central nervous system. It includes the detection, integration, and interpretation of social cues and elaboration of context-specific responses that are quintessentially species-specific. There is an ever-growing accumulation of molecular associations to autism spectrum disorders (ASD), from causative genes to endophenotypes across multiple functional layers; […]
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06/2020 - Neurosci Insights
KMT2B and Neuronal Transdifferentiation: Bridging Basic Chromatin Mechanisms to Disease Actionability
The role of bona fide epigenetic regulators in the process of neuronal transdifferentiation was until recently largely uncharacterized, despite their key role in the physiological processes of neural fate acquisition and maintenance. In this commentary, we describe the main findings of our recent paper “KMT2B is selectively required for neuronal transdifferentiation, and its loss exposes dystonia candidate […]
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