Giuseppe Testa
- Head of Neurogenomics
- Research Group Leader, Testa Group
Giuseppe Testa è un medico, professore ordinario di Biologia Molecolare presso l’Università Statale di Milano e Direttore del High Definition Disease Modelling Lab: Stem Cell and Organoid Epigenetics dell’Istituto Europeo di Oncologia. A Human Technopole il prof. Testa guida il centro di Neurogenomica del programma di ricerca in convenzione con l’Università Statale di Milano. Il programma si occupa, fra l’altro, dei meccanismi molecolari alla base delle disabilità intellettive e dell’autismo.
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Pubblicazioni
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10/2021 - Frontiers in Cellular Neuroscience
Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System
Myelin is the lipidic insulating structure enwrapping axons and allowing fast saltatory nerve conduction. In the central nervous system, myelin sheath is the result of the complex packaging of multilamellar extensions of oligodendrocyte (OL) membranes. Before reaching myelinating capabilities, OLs undergo a very precise program of differentiation and maturation that starts from OL precursor cells […]
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07/2021 - Autophagy
Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders
Macroautophagy (hereafter referred to as autophagy) is a finely tuned process of programmed degradation and recycling of proteins and cellular components, which is crucial in neuronal function and synaptic integrity. Mounting evidence implicates chromatin remodeling in fine-tuning autophagy pathways. However, this epigenetic regulation is poorly understood in neurons. Here, we investigate the role in autophagy […]
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01/2021 - Neuropathology and Applied Neurobiology
Seizure activity and brain damage in a model of focal non‐convulsive status epilepticus
Aims Focal non‐convulsive status epilepticus (FncSE) is a common emergency condition that may present as the first epileptic manifestation. In recent years, it has become increasingly clear that de novo FncSE should be promptly treated to improve post‐status outcome. Whether seizure activity occurring during the course of the FncSE contributes to ensuing brain damage has not been demonstrated unequivocally […]
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12/2020 - The EMBO Journal
COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids
COVID-19 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of SARS-CoV-2’s neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.
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11/2020 - Molecular Autism
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons
Background Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available. Duplication at 7q11.23 (7Dup), encompassing 26–28 genes, is one of the best characterized ASD-causing copy number variations and offers unique translational opportunities, because the hemideletion of […]
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