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Understanding the origin of human brain evolution and the underlying molecular mechanisms is made challenging by the complexity of the brain itself and ethical barriers to the use of human samples. The Kalebic team discusses how human forebrain organoids can be exploited to study human brain evolution and neurodevelopmental pathologies. Human brain evolution has been […]

Three-dimensional (3D) organisation of the eukaryotic nuclear genome has a crucial role in gene regulation. Magda Bienko and Nicola Crosetto overview emerging and established techniques used to investigate the spatial arrangement of the genome in the nucleus and how it affects gene function in single cells and tissues. Tight packing into chromatin fibers and their […]

A research project focussing on rare diseases by Prof. Silvia Nicolis, in the Department of Biotechnology and Biosciences at the University of Milan Bicocca, in collaboration with Veronica Krenn, young researcher among the five winners of the first edition of HT’s Early Career Fellowship (ECF) Programme, and Prof. Giuseppe Testa, Head of the HT’s Neurogenomics […]

Human Technopole is looking for enthusiastic postdoctoral researchers interested in applying for Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2022. Projects should focus on one of the areas of the five HT’s Research Centres: Computational Biology, Structural Biology, Genomics, Neurogenomics and Health Data Science. The objective of PFs is to support researchers’ careers and foster excellence in […]

Thyroglobulin is the protein precursor of thyroid hormones, key regulators of vertebrate development and metabolism. On the occasion of World Thyroid Day, Laura Tosatto and Francesca Coscia discuss how post-translational modifications (PTM) of thyroglobulin can regulate thyroid gland function in health and disease. They also highlight the importance of combining structural biology, proteomics, and genomics […]