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HT Course – BrainOmics

BrainOmics – computational approaches to single-cell multi-omics in neuroscience

Location: Human Technopole, Milan, Italy

Date: Nov 28 – Dec 2, 2022

Target audience: 20 participants selected through application

Deadline for registrations: 30 September 2022

Registration fee: 650 €

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Course Overview

Single-cell omics technologies are breaking new ground in neurobiology by substantially increasing the precision and resolution with which the complex cell populations of the nervous system can be characterised. Approaches that profile several layers of information (genome, epigenome, transcriptome, proteome) allow to generate data of unprecedented depth on the molecular state of the diversity of cells composing the nervous system. 

This increase in data volume and complexity generates as many opportunities as new analytical challenges.

This compact course aims at empowering participants in mastering key computational tools for the analysis of single cell multi-omics datasets, starting from individual molecular layers to then tackle their integration, alongside providing a theoretical overview of the impact of these technologies at the leading edge of neurobiology.

Target Audience

This course is aimed at bioinformaticians and computational biologists with (at least) a basic knowledge of omics techniques.

The core of the course will be centred around hands-on data analysis sessions. A basic understanding of Unix command line, python and/or R is required. Previous experience with single-cell analytical workflow will be considered as an added value to harness the most from the course structure.

Main Topics

Lectures: impact of multimodal approaches on neurobiology research; innovative computational approaches for multi-omics data analysis and integration.

Computational hand-on sessions: key steps and troubleshooting in the analysis of single-cell transcriptomics data; multiplexing approaches and demultiplexing algorithms; analytical workflow for single cell ATACSeq; multi-omics data integration.

Wet Lab demo session: technologies for multimodal single-cell interrogation in neural tissues.

Roundtable with core facilities: structuring integrated multi-omic/functional workflows for neural tissue.

Scientific Organisers

External Speakers and Instructors

  • J. Gray Camp – Group Leader Roche Institute for Translational Bioengineering; Assistant Professor, University of Basel, Switzerland
  • Denis Jabaudon – Professor, University of Geneva, Switzerland
  • Peter Kharchenko – Principal Investigator, Atlos Labs, US
  • Gioele La Manno – Head of the Neurodevelopmental Systems Biology lab, École Polytechnique Fédérale de Lausanne, Switzerland
  • Shahin Mohammadi – Sr. Data Scientist, Insitro, US
  • Genevieve Stein-O’Brien – Assistant Professor, Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, US
  • Bosiljka Tasic – Director, Molecular Genetics, Allen Institute for Brain Science, Seattle, US
  • Joshua Welch – Assistant Professor, Department of Computational Medicine and Bioinformatics University of Michigan, US

HT Speakers and Instructors – Neurogenomics Research Centre

HT Facilities and Support Units

  • Genomics Technologies Development Unit, Genomics Research Centre (Nicola Crosetto, Senior Manager)
  • Automated Stem Cell and Organoid Facility (Giovanni Faga, Head)
  • Image Analysis Facility (Florian Jug, Head)
  • Light Imaging Facility (Nicola Maghelli, Senior Manager)
  • Genomics Facility (Clelia Peano, Senior Manager)
  • Electrophysiology Scientific Service, Neurogenomics Research Centre (Diletta Pozzi, Manager)

Contact: training@fht.org