Andrea Sottoriva
- Head of Computational Biology Research Centre, Biologia Computazionale
- Research Group Leader, Sottoriva Group
Andrea Sottoriva è il responsabile del Centro di ricerca di Biologia Computazionale di Human Technopole.
La ricerca di Andrea si focalizza sullo sviluppo di nuovi approcci computazionali per misurare i processi di evoluzione dei tumori nei pazienti, con lo scopo di effettuare previsioni dello sviluppo della malattia e progettare nuove strategie di trattamento che mirano a controllare la resistenza ai farmaci.
Dopo la laurea in informatica presso l’Università di Bologna nel 2006, ha conseguito un master in scienze computazionali presso l’Università di Amsterdam nel 2008. Durante gli studi del master ha, inoltre, svolto attività di ricerca all’Istituto Nazionale di Fisica Nucleare e delle Alte Energie (NIKHEF) dei Paesi Bassi dove ha lavorato all’esperimento del telescopio per neutrini ANTARES.
Nel 2012 ha ottenuto un dottorato di ricerca in biologia computazionale dall’Università di Cambridge, dove ha lavorato presso il centro di ricerca di Cancer Research UK.
Dopo il post-dottorato presso la University of Southern California, ha avviato il suo laboratorio presso l’Institute of Cancer Research di Londra nel 2013, dove nel 2018 è diventato vicedirettore del Center for Evolution and Cancer e poi direttore nel 2020.
È autore di numerosi studi pubblicati su prestigiose riviste scientifiche tra cui Science, Nature, Nature Genetics e Cancer Discovery. Tra i suoi articoli figurano “The co-evolution of the genome and epigenome in colorectal cancer” (Nature, 2022), “Phenotypic plasticity and genetic control in colorectal cancer evolution” (Nature, 2022), “Subclonal reconstruction of tumors by using machine learning and population genetics” (Nature Genetics, 2020), “Detecting repeated cancer evolution from multi-region tumor sequencing data” (Nature Methods, 2018), “Longitudinal liquid biopsy and mathematical modelling of clonal evolution forecast waiting time to treatment failure in a phase II colorectal cancer clinical trial” (Cancer Discovery, 2018), e “Patient-derived organoids model treatment response of metastatic gastrointestinal cancers” (Science, 2018).
Nel 2016 il Cancer Research UK gli ha conferito il prestigioso premio “Future Leaders in Cancer Research”.
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Pubblicazioni
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10/2022 - Nature
Phenotypic plasticity and genetic control in colorectal cancer evolution
Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity1. The interplay of these biological processes and their respective contributions to tumour evolution remain unknown. Here we show that intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer (CRC). Using spatially resolved paired whole-genome and transcriptome sequencing, […]
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10/2022 - Nature
The co-evolution of the genome and epigenome in colorectal cancer
Colorectal malignancies are a leading cause of cancer-related death1 and have undergone extensive genomic study2,3. However, DNA mutations alone do not fully explain malignant transformation4,5,6,7. Here we investigate the co-evolution of the genome and epigenome of colorectal tumours at single-clone resolution using spatial multi-omic profiling of individual glands. We collected 1,370 samples from 30 primary cancers and […]
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09/2020 - Nature Genetics
Subclonal reconstruction of tumors by using machine learning and population genetics
Most cancer genomic data are generated from bulk samples composed of mixtures of cancer subpopulations, as well as normal cells. Subclonal reconstruction methods based on machine learning aim to separate those subpopulations in a sample and infer their evolutionary history. However, current approaches are entirely data driven and agnostic to evolutionary theory. We demonstrate that […]
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10/2018 - Cancer Discovery
Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial
Sequential profiling of plasma cell-free DNA (cfDNA) holds immense promise for early detection of patient progression. However, how to exploit the predictive power of cfDNA as a liquid biopsy in the clinic remains unclear. RAS pathway aberrations can be tracked in cfDNA to monitor resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer. […]
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08/2018 - Nature Methods
Detecting repeated cancer evolution from multi-region tumor sequencing data
Recurrent successions of genomic changes, both within and between patients, reflect repeated evolutionary processes that are valuable for the anticipation of cancer progression. Multi-region sequencing allows the temporal order of some genomic changes in a tumor to be inferred, but the robust identification of repeated evolution across patients remains a challenge. We developed a machine-learning […]
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